Health & healthcare/ September 2019 –

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Brookings Topic Page on Marijuana
European Centre for Disease Prevention and Control

24 June
A vaccine for Alzheimer’s is on the verge of becoming a reality
For decades, research into Alzheimer’s has made slow progress, but now a mother and daughter team think they have finally found a solution – a vaccine that could inoculate potential sufferers
(Wired UK) Half the deaths in the US in 1900 were from infectious disease. By 2010, mortality related to infectious disease had been all but wiped out, leaving the two biggest killers as cancer and heart disease. Over the last 15 years, UK mortality statistics have shown a steady decline in deaths from heart disease, strokes and most major cancers – for men and women.
Over the same period the death rate from dementia – of which Alzheimer’s is the most common cause – has doubled: in part because lifespans have increased, and the effects of the disease increase with age. In the UK, there are currently 850,000 people living with dementia, and 500,000 – perhaps as many as two-thirds – have Alzheimer’s. In the UK, the Alzheimer’s Society expects dementia sufferers to exceed a million by 2025, with an unknown quantity of carers and family members affected.
A total of five drugs are available to relieve symptoms, but they cannot slow or stop the progression of the disease.
In the last ten years, over 100 anti-Alzheimer’s drugs have been abandoned in development or during clinical trials.
… researchers aren’t sure if high levels of beta-amyloid and tau cause Alzheimer’s or are symptoms of the condition. Both damaged versions of the proteins can cause neighbouring beta-amyloid and tau molecules to misfold as well – spreading the damaging tangles to other cells, breaking nerve cell connections with other neurons and slowly starving neurons to death.
The risks generally increase with age, but an inheritable form of the disease – early-onset Alzheimer’s – can affect people as young as 30. …  Some medications can reduce memory loss and aid concentration, but these just boost the performance of unaffected neurons, doing nothing to stop the kill-off of brain cells.
Chang Yi’s vaccine – UB-311 – couples a synthetic imitation of a common disease with a specific sequence of amino acids that are present only in the damaged beta-amyloid protein, and absent in the healthy form. This provokes an antibody response, clearing the tangled proteins away without provoking potentially damaging inflammation.
In January 2019, the company announced the first results from a phase IIa clinical trial in 42 human patients. “We were able to generate some antibodies in all patients, which is unusual for vaccines,” Chang Yi explains with a huge grin. “We’re talking about almost a 100 per cent response rate. So far, we have seen an improvement in three out of three measurements of cognitive performance for patients with mild Alzheimer’s disease.”
Because phase II trials are so small, there’s no statistically valid evidence yet that UB-311 has an impact on cognition and memory, but the lack of serious side-effects is a big step forward.

Chronically Simple helping manage the chaos of living with chronic disease
The Chronic Disease Prevention Alliance of Canada puts the number of Canadian adults living with chronic disease at 60 per cent. According to Statistics Canada, 6.2 million Canadians over the age of 15 live with one or more disabilities. And nearly half of Canadians have cared for an aging, ill, or disabled family member or friend, according to the agency’s latest data. …
The result was the August 2018 launch of Chronically Simple, a cloud-based app that helps patients and caregivers manage the day-to-day logistics around living with chronic disease or disability, from medication and appointment tracking, to accounting and note taking, to lab results and medical records storage. … Among its many secure features, Chronically Simple offers appointment and scheduling functions, as well as medication and prescription tracking. It’s programmed to send reminders and connect appointment, doctor and prescription details. It also allows the patient to store their own medical records and keep copies of important test results. Users can store important incidentals like tax-deductible parking, travel, equipment, and prescription receipts by taking photos of the receipts. They can also enter appointment notes, manually or via talk-to-text, to be indexed for easy searching by the patient or healthcare provider.

23 September
Liberals, NDP promise increased health care spending
(Globe & Mail) Justin Trudeau promised a re-elected Liberal government would spend an additional $6-billion over four years on health care, describing the promise as a “down payment” to launch negotiations with provinces on pharmacare.
At an announcement in Hamilton, Mr. Trudeau said the increased funding would ensure that every Canadian can “easily” find a family doctor or primary-care team. He said the money would also lead to clear national standards for access to mental-health services, improve home care and implement a rare-disease drug strategy.
Mr. Trudeau gave very few details on the plans for a universal pharmacare system beyond interim measures that were announced in this year’s budget. He did not release a costing for the proposed plan, nor did he say when it would be implemented. Not to be outdone, Greens’ Elizabeth May commits to funding mental health, which she says is affected by the climate crisis
Federal leader outlines her health platform, which includes reducing wait times for assistance programs and putting more money into mental-health services in rural and remote areas.

19 September
Take down the barriers to telemedicine
By Patrick Déry, senior associate analyst at the Montreal Economic Institute.
Given that the technologies behind telemedicine exist and are proven, why do Canada’s health-care systems remain stuck in the past?
(Opinion Montreal Gazette) Because our governments, consciously or not, allow all sorts of obstacles to complicate the lives of patients.
For example, a doctor who provides care to people located in a certain province must hold a licence to practise in that province, even if he or she already holds a licence from another province. This outdated requirement prevents a better allocation of medical resources. If doctors are available to lend a hand in our part of the country, even just temporarily, why not welcome them with open arms?
In the case of telemedicine, the maintenance of this same requirement by the majority of provinces is completely ridiculous. More and more Canadian companies are offering their employees access to virtual consultations through their group insurance plans. A doctor who provides such a consultation could renew a prescription for an Alberta patient, then follow up with another from Manitoba suffering from a chronic illness, direct a Quebec patient to a consultation with a specialist, and give advice to a New Brunswick patient, all without leaving his or her office.
Why force this doctor to hold and renew a licence to practise in each of these places? The anatomy of Canadians does not vary a lot from province to province!
The provincial governments have also set out all sorts of conditions that restrict access to telemedicine within the public systems. It is often reserved for patients who live in remote regions or who suffer from particular conditions. Sometimes, the government even requires the patient or the doctor to go to an authorized health facility to receive or provide virtual care. This defeats at least some of the purpose of telemedicine!
The way we pay doctors doesn’t help, either. Fee-for-service payments, which represent around three-quarters of Canadian doctors’ incomes, do not encourage them to carry out actions for which there will be no payment. Unsurprisingly, the very large majority of our doctors are hesitant to write an email or pick up a phone to contact us, let alone have a smartphone consultation.
Finally, our health-care systems are still often far too centred on doctors. While their expertise is sometimes indispensable, there are many situations in which nurses and pharmacists can lend a hand. Allowing them to do more would liberate doctors, a scarce resource, to do other things.

18 September
Factbox: India becomes latest country to ban sale of e-cigarettes
(Reuters) – India became the latest country after Brazil and Thailand to ban the sale of e-cigarettes in what could potentially be the biggest move against vaping globally over growing health concerns.

6 September
Three more deaths and at least 450 illnesses linked to vaping nationwide
The Centers for Disease Control (CDC) said some type of chemical exposure is likely associated with the illnesses, but more information is needed to determine the exact cause. Many of those hospitalized reported recently vaping a THC product with chemicals from marijuana, while a smaller group reported using regular e-cigarettes.
The CDC did not identify any particular brand of e-cigarette, but expressed concern about any product sold on the street or tampered with by users.
“They’re really concerned about unknown substances people are buying on the street,” LaPook said. “They think it’s not an infection, it’s a probably some chemical irritation. When you think about it, these e-cigarette devices are really like chemistry sets. You put in this liquid, you lick it, you heat it up – there’s some kind of chemical reaction. You’re creating all these different chemicals. You’re not entirely sure what these chemicals are, but we are sure of one thing: You are sucking a lot of them.”

Ebola outbreak in the Democratic Republic of the Congo
(European Centre for Disease Prevention and Control) The 10th outbreak of Ebola virus disease in the Democratic Republic of the Congo (DRC) has been ongoing since August 2018. This is the largest-ever outbreak reported in the country and the world’s second largest in history. It has been declared a Public Health Emergency of International Concern on 17 July 2019.

4 September
Malaria breakthrough as scientists find ‘highly effective’ way to kill parasite
Drugs derived from Ivermectin, which makes human blood deadly to mosquitoes, could be available within two years

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